Clinical Studies

Arvill A, et. al. (1995)
Effect of short-term ingestion of konjac glucomannan on serum cholesterol in healthy men. The American Journal of Clinical Nutrition, 61: 585-589.

Vuksan V, et. al. (1999)
Konjac-mannan (glucomannan) improves glycemia and other associated risk factors for coronary heart disease in type 2 diabetes: a randomized controlled metabolic trial. Diabetes Care, 22 (6): 913-919.

Doi K, et al. (1979)
Treatment of diabetes with glucomannan. Lancet, 5: 987-988.

Ebihara K, et. al. (1981)
Effect of konjac-mannan, a water-soluble dietary fiber on plasma glucose and insulin responses in young men undergone glucose tolerance test. Nutrition Reports International, 23 (4): 577-583.

Doi K, et al. (1981)
Effect of konjac fibre (glucomannan) on glucose and lipids. European Journal of Clinical Nutrition, 49, Suppl.3: S190-197.

Doi K, et al. (1981)
Effect of glucomannan on glucose and lipid metabolism in normal and diabetic subjects. International Congress Environmental Interaction in Diabetes Mellitus. Proceedings of the Third Symposium on Diabetes Mellitus in Asia and Oceania, Honolulu.

Chen-yu H, et. al. (1990)
Effect of konjac food on blood glucose level in patients with diabetes. Biochemical and Environmental Science 3: 123-131.

Doi K, et al. (1983)
Dietary fiber in the treatment of diabetes mellitus. Proceedings of the fourth seminar of diabetes mellitus and nutrition, Kobe, November 22-23: 200-206.

Doi K, et al. (1990)
Metabolic and nutritional effect on long-term use of glucomannan in the treatment of obese diabetics. Y. Oomura et. al. John Libby & Co., Ltd. Progress in Obesity Research: 507-514.

Shima K, et. al. (1971)
Augmented serum insulin response to glucose infusion after the ingestion of konnyaku.

Pro. Soc. Exp. Med., 137: 872-876.
Hopman WPM, et. al. (1988)
Glucomannan prevents postprandial hypoglycemia in patients with previous gastric surgery. Gut, 29: 930-934.

Shima K, et. al. (1982)
Effect of dietary fiber, konjac mannan and sugar gum, on absorption of sulfonylurea in man. Nutrition Reports International, 26: 297-302.

Kneepkens FCM, et. al. (1988)
Dumping syndrome in children. Acta Poediar, Scand. 77: 279-286.

Vorster HH, et. al. (1984)
The effect of long-term ingestion of konjac-glucomannan on glucose tolerance and immunoreactive insulin values on baboons. SA Mediese Tydskrif Deel. May 19: 805-808.

R&D Department, Shimizu Chemical Corporation
Clinical study of propol on obesity II

Walsh DE, et. al. (1984)
Effect of glucomannan on obese patients: a clinical study. International Journal of Obesity, 7: 289-293.

Berrizbeitia ML, et. al.
Glucomannan – dietary fiber action in body weight loss and in the regulation of lipemia values in overweight patients. Military Hospital, Caracas, Department of Cardiology

Rodriguez de Roa E, et. al.
Pharmacologic intervention program in infantile obesity and dislipidemias: usefulness of the dietary fiber glucomannan. Jose Ignacio Baldo Hospital, Cardiology Department, Vargas Hospital, Gastroenterology Department, Risk factors consultation, Caracas, Venezuela.

Livieri C, et. al. (1992)
Impiego di fibre a base di glucomannano altamente purificato nell'obesita infantile (Usefulness of highly purified glucomannan fibers in childhood obesity). Ped. Med. Chr. 14, 195-198 (Italian, English translation).

Vita PM, et. al. (1992)
Impiego cronico del glucomannano nel trattamento delle obesita severe (Chronic use of glucomannan in the dietary treatment of severe obesity). Minerva Med., 83: 135-139 (Italian).

Mao-yu Z, et. al. (1990)
The effect of foods containing refined konjac meal on human lipid metabolism. Biochemical and Environmental Sciences, 3: 99-105.

Biancardi G, et. al. (1989).
Glucomannan in the treatment of overweight patients with osteoporosis. Current Therapeutic Research, 46(5): 908-912.

Salvatoni S, et. al. (1991).
Quadro lipidico ed eccesso ponderale nell'obesita infantile: influenza di un supplemento farmacologico alla dieta. (Serum lipids in obese children: a double blind controlled trial on treatment by diet only vs. diet and drugs). Peg. Oggi, 11(9): 243-245 (Italian, English translation).

Reffo GC, Ghirardi PE, & Forattini C (1988)
Glucomannan in hypertensive outpatients: pilot clinical trial. Current Therapeutic Research; 44(1): 22-27.

Cairella M, & Marchini G (1995)
Glucomannano e obesita: valutazione dell'attivita del glucomannano su alcuni parametric metabolici e sulla senzazione di sazieta in pazienti con sorvapresso de obesita. Clin. Ter. 146: 269-274 (Italian).

Chen HL, et. al. (2003)
Konjac supplement alleviated hypercholesterolemic and hyperglycemia in type 2 diabetic subjects: a randomized double blind trial. Journal of the American College Nutrition, 22 (1): 36-42.

Vuksan V, et. al. (2000)
Beneficial effects of viscous dietary fiber from konjac-mannan in subjects with the insulin resistance syndrome: results of a controlled metabolic trial. Diabetes Care, 23 (1): 9-14.

Terasawa F, et. al. (1979)
The effects of konjac flour on the blood lipids in the elderly subjects. Japan Journal of Nutrition, 37 (1): 23-28.

Kiriyama S, et. al. (1974)
Inhibitory effect of konjac manna on bile acid transport in the everted sacs from rat ileum. The Journal of Nutrition, 104: 69-78.

Ebihara K, et. al. (1989)
Interaction of bile acids, phopholipids, cholesterol and triglyceride with dietary fibers in the small intestine of rats. American Journal of Nutrition: 1100-1106.

Reffo GC, Ghirardi PE, Forattini C. (1990)
Double-blind evaluation of glucomannan versus placebo in postinfarcted patients after cardiac rehabilitation. Current Therapeutic Research, 47(5): 753-758.

Cesa T, et. al. (1990)
Utillizzazione delle fibre vegetali per la terapia del deabete gestazionale c/o dell eccesivo aumento ponderale in gravidanza. (User of vegetable fiber in the treatment of gestational diabetes and/or excessive weight gain in pregnancy). Minerva Ginecologica, 42: 271-274 (Italian).

Magnati G, et. al. (1984)
Fibre dietetichie de OGTT: variazioni glicemiche dopo somministrazione di un nuovo glucomanno purificato. Act Biomedica de , 55: 15-14 (Italian)

Marsicano LJ, et. al.
Use of the glocomannan dietary fiber in the modification of the intestinal habit. Vargas Hospital, Caracas, Department of Gastroenterology. Military Hospital, Caracas, Department of Cardiology.

Rosado JL, et. al.
Composition and phycho-chemical properties of different sources of dietary fiber with its gastrointestinal effect. Department do Fisiologia de la Nutrition, Instituto Nacional de la Nutrition Salvador Zubiran.

Vuksan V, et. al. (2001)
Konjac-mannan and American ginsing: emerging alternative therapies for type 2 diabetes mellitus. Journal of American College Nutrition, 20(5): 370S-380S.

Ebihara K, et. al. (1981)
Major determinants of plasma glucose – flattening activity of a water-soluble dietary fiber: effect of konjac mannan on gastric emoting and intraluminal glucose-diffusion. Nutrition Reports International, 23(6): 1145-1156.

Passaretti S, et. al. (1991)
Action of Glucomannan on complaints in patients affected with chronic constipation: a multicentric clinical evaluation. The Italian Journal of Gastroenterology, 23(7): 421-425.

Staiano A, et. al. (2000)
Effect of the dietary fiber glucomannan on chronic constipation in neurologically impaired children. The journal of Pediatrics, 136 (1): 41-45.

Marzio L, et. al. (1989)
Mouth-to-cerum transit time in patients affected by chronic constipation: effect of glucomannan. American Journal of Gastroenterology, 84 (8): 888-891.

Kiriyama S, et. al.
Hypoclesterolemic effect if polysaccharies and polysaccharide-rich foodstuffs in cholesterol-fed rats. Journal of Nutrition, 97: 382-388.

Gallaher CM., et al. (2000)
Cholesterol reduction by glucomannan and chitosan is mediated by chnages in cholesterol absorption and bile acid and fat excretion in rats. Nutrient Metabolism, American Society for Nutritional Sciences: 2753-2759.

Lim BO, et. al. (1997)
Dietary fibers modulated indices of intestinal immune function in rats. Biochemical and molecular roles of nutriets. American Society of Nutritional Sciences: 663-667.

MacKenzie KM, et. al.
Dose-Response Study with Glucomannan in Rats. Hazelton Laboratories America Inc.

Mizutani T, et. al. (1998)
Effect of konjac mannan on intestinal microflora and tumorigenesis. First International Meeting on Intestinal Microflora, Gastroenterology International, 2, Suppl. 1: 52-55.

Mizutani T, et. al. (1987)
Influence of dietary konjac mannan on fecal microflora in f344 rats. Proc. Japan Acad., 63: 273-276.

Mizutani T, et. al. (1980)
Inhibitory effect of some intestinal bacteria on liver tumorigenesis gnotobiotic c3h/he male mice. Elsevier Scientific Publishers Ireland Ltd. Cancer Letters, 11: 89-95

Mizutani T, et. al. (1982)
Effect of konjac mannan on spontaneous liver tumorigenesis and fecal flora in c3h/he male mice. Elsevier Scientific Publishers Ireland Ltd. Cancer Letters, 17: 27-32.

Mizutani T, et. al. (1983)
Effect of konjac mannan on 1, 2-dimethydrazine-induced intestinal carcinogenesis in Fischer 344 rats. Elsevier Scientific Publishers Ireland Ltd. Canter Letters, 19: 1-6.

Fujiwara S, et. al. (1991)
Effect of konjac mannan on interstinal microbial metabolism in mice bearing human flora and in conventional F344 rats. Fd. Chem. Toxic. 29(9): 601-606.